Prognostic markers of acute decompensated heart failure: the emerging roles of cardiac biomarkers and prognostic scores

Prognostic markers of acute decompensated heart failure: the emerging roles of cardiac biomarkers and prognostic scores

Cohen-Solal A1Laribi S2Ishihara S3Vergaro G4Baudet M5Logeart D6Mebazaa A7Gayat E7Vodovar N8Pascual-Figal DA9Seronde MF10. Arch Cardiovasc Dis. 2015 Jan;108(1):64-74.

Source : 1UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Cardiology department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France; DHU FIRE, Sorbonne Paris Cité, Paris, France. Electronic address: alain.cohen-solal@inserm.fr. 2UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Emergency department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, Paris, France. 3UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Cardiology department, Steel Memorial Yawata Hospital, Kitakyushu, Japan. 4UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Cardiology and cardiovascular medicine division, Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica, CNR-Regione Toscana, Pisa, Italy. 5Cardiology department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France. 6UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Cardiology department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75010 Paris, France; DHU FIRE, Sorbonne Paris Cité, Paris, France. 7UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; DHU FIRE, Sorbonne Paris Cité, Paris, France; Anaesthesia-ICU department, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, Paris, France. 8UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France. 9Cardiology department, hospital Virgen de la Arrixaca, school of medicine, university of Murcia, Murcia, Spain. 10UMR-S 942 “Biomarqueurs et Insuffisances Cardiaques”, Paris, France; Cardiology department, CHU de Besançon, Besançon, France.

Abstract: Rapidly assessing outcome in patients with acute decompensated heart failure is important but prognostic factors may differ from those used routinely for stable chronic heart failure. Multiple plasma biomarkers, besides the classic natriuretic peptides, have recently emerged as potential prognosticators. Furthermore, prognostic scores that combine clinical and biochemical data may also be useful. However, compared with the scores used in chronic heart failure, scores for acute decompensated heart failure have not been validated. This article reviews potential biomarkers, with a special focus on biochemical biomarkers, and possible prognostic scores that could be used by the clinician when assessing outcome in patients with acute heart failure.